Editorial: Non-cell Cycle Functions of Cell Cycle Regulators
نویسندگان
چکیده
منابع مشابه
Altered expression of cell cycle regulators in adult T-cell leukemia/lymphoma patients
Abstract Background: Adult T-cell leukemia/lymphoma (ATLL) is caused by human T-cell lymphotropic virus type-1 (HTLV-1). HTLV-1 oncogenes can induce malignancy through controlled gene expression of cell cycle checkpoints in the host cell. HTLV-I genes play a pivotal role in overriding cell cycle checkpoints and deregulate cellular division. In this study, we aimed to determine and comp...
متن کاملSnapShot: Cell-Cycle Regulators II
function S. cerevisiae (Budding Yeast) S. pombe (fission Yeast) D. melanogaster (fruit fly) X. laevis (clawed Toad) H. sapiens (Human) Cdk-inhibitory kinases Phosphorylate Cdk in active site, blocking activity swe1 Wee1, Mik1 Dwee1, Dmyt1 Wee1, Myt1 Wee1, Myt1 Cdk-activating phosphatases Dephosphorylate inhibitory phosphorylation of Cdk subunit
متن کاملSnapShot: Cell-Cycle Regulators I
function Phase S. cerevisiae (Budding Yeast) S. pombe (fission Yeast) D. melanogaster (fruit fly)
متن کاملModulation of cell cycle regulators by HDACs.
Histone deacetylases (HDACs) catalyze the deacetylation of lysine residues on histones and non-histone proteins. HDACs have been shown to control the functions of key cell cycle proteins. Consistent with this, the overexpression of HDACs has been observed in multiple cancers, resulting in deregulation of the cell cycle and uncontrolled proliferation. This review focuses on the impact that HDACs...
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Most tumor suppressor genes (whose function in cancer biology was surmised by their inactivation or deletion) turn out to be important in normal cell growth and proliferation. Inactivation of these genes opens the gates to malignant transformation driven by aberrant growth signals. In general, tumor suppressor dysfunction does not initiate genomic instability or aneuploidy, hallmarks of the ori...
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ژورنال
عنوان ژورنال: Frontiers in Cell and Developmental Biology
سال: 2019
ISSN: 2296-634X
DOI: 10.3389/fcell.2019.00122